Chin. J. Org. Chem. ›› 1988, Vol. 8 ›› Issue (2): 164-166. Previous Articles     Next Articles

使用手性相转移催化剂合成D-苯丙氨酸

陈金泰;陈耀焕;盛怀禹   

  1. 中国科学院上海有机化学研究所
  • 发布日期:1988-04-25

Synthesis of D-phenylalanine using chiral phase-transfer catalyst

CHEN JINTAI;CHEN YAOHUAN;SHENG HUAIYU   

  • Published:1988-04-25

D-Phenylalanine with 89.9% optical purity was successfully synthesized by benzylation of N-benzylideneglycine Et ester under phase-transfer conditions using (-)-N-benzylcinchonidinium chloride as catalyst and dichloromethane as solvent, followed by hydrolysis of the resulting product. In the cases of several more polar solvents the resulting D-phenylalanine had lower optical purities.

Key words: ETHYL ESTER, PHENYLALANINE, PHASE TRANSFER CATALYST, GLYCINE, CHIRALITY

CLC Number: