Chin. J. Org. Chem. ›› 1998, Vol. 18 ›› Issue (5): 437-441. Previous Articles     Next Articles

Original Articles

邻二甲胺基苄氯衍生物与取代的2-巯基苯并咪唑 反应规律探索

杨日芳;恽榴红;丁振Kai   

  1. 军事医学科学院毒物药物研究所.北京(100Act)
  • 发布日期:1998-10-25

Stuides on the nucleophilic reaction rules of derivatives of 2- dimethylaminobenzylchloride reacting with substituted 2- mercaptobenzimidazole

Yang Rifang;Yun Liuhong;DING ZHE   

  1. Institute of Pharmacology and toxicology Academy of Military Med. Beijing(100Act)
  • Published:1998-10-25

Both S-condensation and N-condensation reaction could take place when derivatives of 2-dimethylaminobenzylchloride react with substituted 2-mercapto-benzimidazole, mainly depending on the substituted groups of 2-dimethylaminobenzyl-chloride. It is important to control the reaction toward the desired S-condensation in order to produce the key intermediate of a novel type of proton pump inhibitor. The rules and controlling methods of the reaction were proposed. The key intermediates which are difficult to prepare by the literature method may be synthesized by using the improved method 3, that is derivatives of 2-dimethylaminobenzylchloride react with sodium salt of substituted 2-mercaptobenzimidazole.

Key words: RULES, MERCAPTO COMPOUNDS, QUANTUM CHEMISTRY, NUCLEOPHILIC REACTION, CALCULATION, ORGANO CHLORIDE COMPOUNDS, SUBSTITUTION REACTION, DIMETHYLAMINO, BEN ZYL GROUP P, BENZIMIDAZOLE P

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