Chin. J. Org. Chem. ›› 2000, Vol. 20 ›› Issue (5): 815-819. Previous Articles     Next Articles

三氯化铁催化的一锅法合成3,4-二氢嘧啶-2-酮

路军;马怀让;李万华   

  1. 西北大学化学系.西安(710069);西北大学化学工程系.西安(710069)
  • 发布日期:2000-10-25

A novel one-pot synthesis of 3,4-dihydropyrimidine-2(1H)-ones by catalyzed ferric chloride hexahydrate

Lu Jun;Ma Huairang;Li Wanhua   

  1. Northwest Univ, Dept Chem.Xian(710069);Northwest Univ, Dept Chem Eng. Xian(710069)
  • Published:2000-10-25

The syntheses of dihydropyrimidinones by a one-pot cyclocondensation of aldehydes, β-keto ester, and ureas (1:1:1.5) using ferric chloride hexahydrate as catalyst and alcohol as solvent are presented. The modified one-pot Biginelli's cyclocondensation not only features short reaction period, simple operation and high yield (80%~90%), but also is environment friendly.

Key words: IRON CHLORIDE, CYCLIZATION, CONDENSATION REACTION, CATALYST, PYRIMIDONE P

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