Synthesis and amtitumor activity of diphenylgermanium  heterocyclic carboxylates

Chin. J. Org. Chem. ›› 2001, Vol. 21 ›› Issue (1): 41-44. Previous Articles Next Articles

二苯基锗杂环羧酸酯的合成、表征及生物活性研究

张如芬;尹汉东;马春林;邵鑫

中国科学院兰州化学物理研究所.兰州(730000);中国科学院兰州化学物理研究所.兰州(730000)

发布日期:2001-01-25

Synthesis and amtitumor activity of diphenylgermanium heterocyclic carboxylates

Zhang Rufen;Yin Handong;Ma Chunlin;Shao Xin

Lanzhou Inst Chem Phys, CAS.Lanzhou(730000);Lanzhou Inst Chem Phys, CAS.Lanzhou(730000)

Published:2001-01-25

Abstract

Eight new diphenylgermanium heterocyclic carboxylates PH2Ge(O2CR) 2were synthesized by reaction of diphenylgermanium chloride with sodium heterocyclic carboxylates. Their structures were established by elemental analysis,IR,1^H NMR and MS spectorscops.The IR spectra show that in complexes 1～ 8 the carboxyl groups are bidentate ligands. The complexes 1～ 8 all display much higher activity in vitro than those of cis-platin or triphenylgermanium chloride in the experiments against two human tumor cell lines, MCF-7, a mammary tumor, WiDr, a colon carcinoma,and EC, an ascites carcinoma.

Key words: ORGANO GERMANIUM, ANTICARCINOGEN, CARBOXYLIC ACID ESTER, HETEROCYCLIC COMPOUNDS, STRUCTURE CHARACTERISTICS, BIOLOGICAL ACTIVITY

CLC Number:

O627

Cite this article

Zhang Rufen;Yin Handong;Ma Chunlin;Shao Xin. Synthesis and amtitumor activity of diphenylgermanium heterocyclic carboxylates[J]. Chin. J. Org. Chem., 2001, 21(1): 41-44.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

[1]	Mingjia Guang, Shuo Jiang, Baoyu Zhu, Rusong Zhang, Kunpeng Wang, Minghui Wang, Liangzhong Xu. Design, Synthesis and Insecticidal, Acaricidal Activities of Novel Pyrrole-2-carboxylic Acid and Their Derivatives [J]. Chinese Journal of Organic Chemistry, 2023, 43(8): 2895-2904.
[2]	Yuzhuo Chen, Hongmei Sun, Liang Wang, Fangzhi Hu, Shuaishuai Li. Research Progress on Construction of Heterocyclic Skeletons Based on α-Hydride Transfer Strategy [J]. Chinese Journal of Organic Chemistry, 2023, 43(7): 2323-2337.
[3]	Qifan Wang, Yuanquan Zhang, Li Xing, Yuanxiang Zhou, Chenyu Gong, Bangcan He, Nian Zhang, Yongjun Wu, Wei Xue. Design, Synthesis and Biological Activity of Myricetin Derivatives Containing 1,2,4-Triazolo[3,4-b]-1,3,4-thiadiazole [J]. Chinese Journal of Organic Chemistry, 2023, 43(4): 1525-1536.
[4]	Kanghui Duan, Junlong Tang, Wanqing Wu. Recent Advances in the Synthesis of Fused Heterocyclic Compounds and Their Antitumor Activities [J]. Chinese Journal of Organic Chemistry, 2023, 43(3): 826-854.
[5]	Qiushan Gao, Meng Li, Wanqing Wu. Recent Advances in Transition Metal-Catalyzed Isocyanide Insertion Reactions [J]. Chinese Journal of Organic Chemistry, 2022, 42(9): 2659-2681.
[6]	Bangkui Yu, Hanmin Huang. Recent Advances in C—X Bond Metathesis Reactions [J]. Chinese Journal of Organic Chemistry, 2022, 42(8): 2376-2389.
[7]	Can Yong, Yun Li, Tao Bi, Guofeng Chen, Dongxia Zheng, Zhouyu Wang, Yuanyuan Zhang. Research Progress on the Synthesis and Activity of D-Galactose Derived Small Galectin Inhibitors [J]. Chinese Journal of Organic Chemistry, 2022, 42(5): 1307-1325.
[8]	Jie Luo, Yaqian Yan, Haoxin Wang, Yaoyao Li. Discovery of a New Polycyclic Tetramate Macrolactam Clifednamide K [J]. Chinese Journal of Organic Chemistry, 2022, 42(4): 1224-1228.
[9]	Yajun Mao, Xiangmin Shao, Yangjie Li, Ruimei Cao, Yali Feng, Guangyu Zhai. Research Progress on the Synthesis of Quercetin Derivatives [J]. Chinese Journal of Organic Chemistry, 2022, 42(11): 3588-3605.
[10]	Hongliang Xu, Jing Su, Zishi Wang, Chenxin Hou, Pengchong Wu, Yue Xing, Xiangshuai Li, Xiaolei Zhu, Yuncai Lu, Lijian Xu. Synthesis, Design and Three-Dimensional Quantitative Structure Activity Relationship (3D-QSAR) Research of Phenylpyrrole Fungicides [J]. Chinese Journal of Organic Chemistry, 2021, 41(9): 3560-3570.
[11]	Xiaotian Qin, Junchao Zhang, Yuqing He, Rui Zhang, Hua Cheng, Cheng Chen, Xin Qin. Synthesis and Biological Activities of Coenzyme Q Derivatives Containing (4-Aryloxylaryl)amino Moiety [J]. Chinese Journal of Organic Chemistry, 2021, 41(5): 2045-2054.
[12]	Meng Xu, Shenyuan Gao, Yuanxu Zeng, Anhui Gao, Lixin Gao, Lei Xu, Yubo Zhou, Jianrong Gao, Qing Ye, Jia Li. Synthesis and Evaluation of 3-(Indol-3-yl)-4-(pyrazolo[3,4- c]pyridazin-3-yl)maleimides as Potent Mutant Isocitrate Dehydrogenase-1 Inhibitors [J]. Chinese Journal of Organic Chemistry, 2021, 41(5): 1991-2000.
[13]	Ting Jiang, Hong Pu, Yanwen Duan, Xiaohui Yan, Yong Huang. New Natural Products of Streptomyces Sourced from Deep-Sea, Desert, Volcanic, and Polar Regions from 2009 to 2020 [J]. Chinese Journal of Organic Chemistry, 2021, 41(5): 1804-1820.
[14]	Fengcheng Jia, Na Luo, Cheng Xu, Anxin Wu. Recent Advances in the Synthesis of Benzoheterocyclic Compounds Involving Isatins [J]. Chinese Journal of Organic Chemistry, 2021, 41(4): 1527-1542.
[15]	Yaqin Zhou, Zhiheng Zhao, Liang Zeng, Ming Li, Yonghui He, Lijun Gu. Recent Advance in Organic Electrochemical Synthesis of Nitrogenous Heterocyclic Compounds Involving Haloids as Mediators [J]. Chinese Journal of Organic Chemistry, 2021, 41(3): 1072-1080.

二苯基锗杂环羧酸酯的合成、表征及生物活性研究

Synthesis and amtitumor activity of diphenylgermanium heterocyclic carboxylates

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments