Synthesis of Hydrocortisone Glycosylamine Derivatives

Abstract

A convenient procedure for the synthesis of hydrocortisone glycosylamine derivatives is described. Hydrocortisone was converted to succinate derivative 2; glucose, 2-TV-acetyl-glucose, galactose, lactose and 2-amino-2-deoxy-D-glucopyranose hydrochloride were transferred into corresponding glycosylamines (7a, 7b, 7c, 7d and 12). Then the amidation of 2 with glycosylamines was carried out in the presence of DCC to furnish the derivatives 13a~ 13e. The structures of the products were characterized by IR, `H NMR, ~13C NMR and HRMS.

Key words: hydrocortisone, AMINO SUGAR, STEROL, steroid glycoside, IR, 1HNMR

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Cite this article

Qu Feng;Li YingXia;Song Ni. Synthesis of Hydrocortisone Glycosylamine Derivatives[J]. Chin. J. Org. Chem., 2003, 23(4): 361-367.

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