Chin. J. Org. Chem. ›› 2003, Vol. 23 ›› Issue (4): 390-392. Previous Articles     Next Articles

手性仲丁胺的制备拆分和光学纯度的测定

车超;代星;毛淑芬;徐彦军;覃兆海   

  1. 中国农业大学应用化学学院
  • 发布日期:2003-04-25

Preparative Resolution and Enantiomeric Purity Assessment of sec- Butylamine

Che Chao;Dai Xing;Mao ShuFen;Xu YanJun;Qin ZhaoHai   

  1. College of Applied Chemistry,China Agricultural University
  • Published:2003-04-25

Using D- or L-tartaric acid as resolving agent, a method was established to resolve sec-butylamine intoboth of its pure enantiomers with o. p. > 99% , and the enantiomeric purities were assessed by P NMR after the formation of the cyclic phosphoramidate with 7?-BINOPCl. The resolving agents were conveniently recovered by passing the acidified solution through a sulfonie resin (001x7x7) column with > 80% recovery yield.

Key words: buytlamine, ISOMER, TARTARIC ACID, CRYSTAL STRUCTURE, ION EXCHANGE RESINS

CLC Number: