3-Bromothiophene and 3,4-dibromothiophene were synthesizedin high yields from thiophene, 48% (m/m) aqueous hydrobromic acid, 35% (m/m) aqueous hydrogen peroxide solution, anhydrous liquid ammonia and sodium. Inthe presence of (dppp)NiCl₂, 3-bromothiophene and 3,4-dibromothiophene reacted with Grignard reagents to afford 3-alkylthiophene and 3,4-dialkylthiophenein good yields, respectively. 3-Alkoxythiophene was synthesized from 3-bromothiophene and alcohol using CuI and anhydrous sodium bisulfate as catalysts. Thecompounds obtained were characterized by ¹H NMR, MS spectra and elementalanalysis.

Key words: thiophene derivative, synthesis, characterization