Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (10): 1296-1299. Previous Articles     Next Articles

N-取代芳环-4-氨基喹唑啉类化合物的合成及生物活性研究

刘刚, 宋宝安*, 桑维钧, 杨松, 金林红, 丁雄   

  1. 贵州大学精细化工研究开发中心教育部绿色农药和农业生物工程重点实验室 贵阳 550025
  • 收稿日期:2003-08-12 修回日期:2004-03-02 接受日期:2004-04-29 发布日期:2022-09-20
  • 基金资助:
    国家重大基础研究发展计划(973计划)(No. 2003CB114404)、 国家863计划(No. 2002AA217131)、 国家自然科学基金(No. 20162001)和2002年贵州省国际合作(黔科合国字[2002]11002号)资助项目.

Synthesis and Bioactivity of N-Aryl-4-aminoquinazoline Compounds

LIU Gang, SONG Bao-An*, SANG Wei-Jun, YANG Song, JIN Lin-Hong, DING Xiong   

  1. Key Laboratory of Green Pesticide & Agricultural Biological Engineering, Ministry of Education, Research and Development Centre of Fine Chemicals, Guizhou University, Guiyang 550025
  • Received:2003-08-12 Revised:2004-03-02 Accepted:2004-04-29 Published:2022-09-20
  • Contact: * E-mail: gzgdjh@tmail.gzu.edu.cn; Fax: 0851-3622211.

Three new N-aryl-4-aminoquinazolinecompounds were synthesized by the reaction of 4-chloroquinazoline with arylamines. The structures of the three new compounds were characterized by elemental analyses, IR and 1H NMR spectra. Bioactivity of the new compounds was tested. The results showed that the three new compounds had some antifungal activities.

Key words: quinazoline, synthesis, bioactivity