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Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (10): 1300-1303. Previous Articles     Next Articles

通过氧杂Pictet-Spengler反应从1-烷(苯)氧基-3-(3,4-亚甲基二氧)苯基-2-丙醇合成异色满衍生物

赵宝祥*, 沙磊, 谭伟, 左华, 王大威   

  1. 山东大学化学与化工学院有机化学研究所 济南 250100
  • 收稿日期:2003-11-19 修回日期:2004-02-11 接受日期:2004-04-30 发布日期:2022-09-20
  • 基金资助:
    山东省自然科学基金(No. Z2002D05)和教育部重点(No. 104112)资助项目.

Synthesis of Isochroman Derivatives from 1-Alkoxy (phenoxy)-3-(3,4- methylenedioxy)phenyl-2-propanol by Oxa-Pictet-SpenglerReaction

ZHAO Bao-Xiang*, SHA Lei, TAN Wei, ZUO Hua, WANG Da-Wei   

  1. Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100
  • Received:2003-11-19 Revised:2004-02-11 Accepted:2004-04-30 Published:2022-09-20
  • Contact: * E-mail: bxzhao@sdu.edu.cn; Fax: 86-531-8564464.

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A series of isochromanic derivatives, 3-alkoxy(phenoxy)-1-phenyl-6,7-methylenedioxyisochromans and 3-alkoxy(phenoxy)-1,1-dimethyl-6,7-methylenedioxyisochromans were synthesized from 1-alkoxy-3-(3,4-methylenedioxy)phenyl-2-propanol and 1-phenoxy-3-(3,4-methylenedioxy)phenyl-2-propanol by the oxa-Pictet-Spengler reaction in 50%～90% yields.

Key words: isochromanic derivative, oxa-Pictet-Spengler reaction, synthesis