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Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (12): 1606-1609. Previous Articles     Next Articles

N-取代苯基-N′-(1,3,4-噻二唑-2-基)脲类化合物的合成与生物活性

汪焱钢*,a, 王子云b, 赵新筠c, 宋新建a   

  1. a华中师范大学化学学院 武汉 430079
    b周口师范学院化学系 周口 466000
    c南阳师范学院化学系 南阳 473000
  • 收稿日期:2004-03-12 修回日期:2004-06-14 接受日期:2004-06-14 发布日期:2022-09-20
  • 基金资助:
    江苏省青蓝工程基金(No. QL98001)和江苏省高校自然科学基金(No. 04KJB150139)资助项目

Synthesis and Biological Activity of N-Substitutedphenyl- N′-(1,3,4-thiodiazol-2-yl)ureas

WANG Yan-Gang*,a, WANG Zi-Yunb, ZHAO Xin-Yunc, SONG Xin-Jiana   

  1. aCollege of Chemistry, Central China Normal University, Wuhan 430079
    bDepartment of Chemistry, Zhoukou Normal University, Zhoukou 466000
    cDepartment of Chemistry, Nanyang Normal University, Nanyang 473000
  • Received:2004-03-12 Revised:2004-06-14 Accepted:2004-06-14 Published:2022-09-20
  • Contact: *E-mail: xswang1974@yahoo.com or xswang@xznu.edu.cn

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Ten new N-substituted phenyl-N′-(1,3,4-thiodiazol-2-yl)ureas have been synthesized by the reaction of acylazides with 2-amino-1,3,4-thiodiazole or 5-amino-2-mercapto-1,3,4-thiodiazole. Their structures have been confirmed by 1H NMR, IR spectra and elemental analysis. Preliminary biological activity tests show that some of the target compounds (2c and 2d) have the same good activity as cytokinin.

Key words: thiodiazole, urea, synthesis, cytokinin, biological activity