Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (12): 1610-1613. Previous Articles     Next Articles

超声辐射合成5,7-二取代-2-(5-芳基-2-呋喃甲酰亚胺)-[1,2,4]-噻二唑并[2,3-a]嘧啶衍生物及其生物活性研究

薛思佳, 柯少勇*, 段李平, 李景智   

  1. 上海师范大学 生命与环境科学学院 上海 200234
  • 收稿日期:2004-01-05 修回日期:2004-06-15 接受日期:2004-06-15 发布日期:2022-09-20
  • 基金资助:
    江苏省“青蓝工程”科研基金(No. QL9801)、江苏省药用植物生物技术重点实验室基金(No. 02AXL13)、徐州师范大学研究生科研创新资助项目

Ultrasonically Irradiated Synthesis and Bioactivity of 5,7-Disubstituted-2-(5- aryl-2-furoylimino)-[1,2,4]-thiadiazolo[2,3-a]pyrimidine Derivatives

XUE Si-Jia, KE Shao-Yong*, DUAN Li-Ping, Li Jing-Zhi   

  1. College of Life and Environment Science, Shanghai Normal University, Shanghai 200234
  • Received:2004-01-05 Revised:2004-06-15 Accepted:2004-06-15 Published:2022-09-20
  • Contact: *E-mail: dqshi@263.net

Eight new 5,7-disubstituted-2-(5-aryl-2-furoylimino)-[1,2,4]-thiadiazolo[2,3-a]pyrimidine derivatives were synthesized under ultrasonic irradiation. All of them are new compoundsand their structures were exactly confirmed by IR, 1H NMR spectra and elemental analysis. Our method using the ultrasonic irradiation under the conditionof phase transfer catalyst (PTC) has the advantages of short reaction time andgood yield. The preliminary biological tests show that some of the target compounds have some inhibitory activities against weeds.

Key words: acyl thiourea, [1,2,4]-thiadiazolo[2,3-a]pyrimidine, ultrasonic irradiation, phase transfer catalysis, synthesis, bioactivity