Synthesis of 2,3-Disubstituted-5-hydroxybenzofuran Derivatives

Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (12): 1637-1639. Previous Articles Next Articles

2,3-二取代-5-羟基苯并呋喃衍生物的合成

全哲山^*, 赵立明, 李福男, 朴虎日

延边大学医学院延吉 133000

收稿日期:2004-04-19 修回日期:2004-10-08 接受日期:2004-10-12 发布日期:2022-09-20

Synthesis of 2,3-Disubstituted-5-hydroxybenzofuran Derivatives

QUAN Zhe-Shan^*, ZHAO Li-Ming, LI Fu-Nan, PIAO Hu-Ri

College of Pharmacy, Yanbian University, Yanji 133000

Received:2004-04-19 Revised:2004-10-08 Accepted:2004-10-12 Published:2022-09-20
Contact: *E-mail: quanzheshan@yahoo.com.cn

Abstract

2,3-Disubstituted-5-hydroxybenzofurans were synthesized by the condensation of 1,4-cyclohexanedione with 1,2-diones. The structures of the target compoundswere confirmed by IR, ¹H NMR and MS spectra. The reaction conditions werediscussed. The results showed that the condensation using LiCl as a catalyst, DMI as a solvent at 200 ℃ for 1 h gave the better yields.

Key words: 1,4-cyclohexanedione, 2,3-butanedione, 2,3-dimethyl-5-hydroxybenzofuran, synthesis

Cite this article

QUAN Zhe-Shan, ZHAO Li-Ming, LI Fu-Nan, PIAO Hu-Ri. Synthesis of 2,3-Disubstituted-5-hydroxybenzofuran Derivatives[J]. Chinese Journal of Organic Chemistry, 2004, 24(12): 1637-1639.

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2,3-二取代-5-羟基苯并呋喃衍生物的合成

Synthesis of 2,3-Disubstituted-5-hydroxybenzofuran Derivatives

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