Three Component One-Pot Synthesis of Pyrido[2,3-d]pyrimidineDerivatives Catalyzed by KF-alumina

Abstract

A series of pyrido[2,3-d]pyrimidine derivatives were synthesized by the three component reaction of arylaldehyde, malononitrile and 4-amino-2,6-dihydroxylpyrimidine in ethyl alcohol at 80 ℃ catalyzed by KF-Al₂O₃. It was interesting that the further aromatization took place by air oxidation. Compared with other synthetic methods, this new method has the advantage of easier work-up, milder reaction conditions and good yields. The structure of the products was characterized by IR, ¹H NMR spectra and elemental analysis.

Key words: aromatization, KF-Al₂O₃, synthesis, pyrido[2,3-d]pyrimidine

Cite this article

WANG Xiang-Shan*^,1,2,3,ZENG Zhao-Sen²,SHI Da-Qing^2,3,TU Shu-Jiang^2,3
WEI Xian-Yong,ZONG Zhi-Min. Three Component One-Pot Synthesis of Pyrido[2,3-d]pyrimidineDerivatives Catalyzed by KF-alumina[J]. Chin. J. Org. Chem., 2006, 26(02): 256-259.

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KF/Al₂O₃催化下吡啶并[2,3-d]嘧啶衍生物的三组分一步合成