2,3,4,6-Tetra-acetyl-β-D-glucopyranosyl thioureas IV were synthesized by the reaction aniline with 2,3,4,6-tetra-acetyl-β-D-glucopyranosyl isothiocyanate generated from 1-bromo-2,3,4,6-tetra-acetyl-α- D-glucopyranuronate and KSCN in reflux acetonitrile. In the synthesis of acetyl-β-D-glucopyranosyl isothiocyanate, the yield was raised from 60% to 80%. The structures of the compounds were confirmed by IR, MS, NMR spectra and elemental analysis. The preliminary biological tests indicate that some compouds of IV and V show good herbicidal activity.

Key words: synthesis, biological activity, glucosyl thiourea