Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (06): 845-847. Previous Articles     Next Articles

Original Articles

含羟基和咪唑基团新手性肽核酸的设计与合成

孟庆国*,1,许笑宇2,梁远军2,刘克良2   

  1. (1烟台大学药学院 烟台 264005)
    (2军事医学科学院毒物药物研究所 北京 100850)
  • 收稿日期:2005-09-13 修回日期:2006-03-17 发布日期:2006-05-31
  • 通讯作者: 孟庆国

Design and Synthesis of New Chiral Peptide Nucleic Acids Containing Hydroxyl and Imidazole Groups

MENG Qing-Guo*,1,XU Xiao-Yu2,LIANG Yuan-Jun2,LIU Ke-Liang2   

  1. (1 School of Pharmacy, Yantai University, Yantai 264005)
    (2 Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850)
  • Received:2005-09-13 Revised:2006-03-17 Published:2006-05-31
  • Contact: MENG Qing-Guo

Five new 10-mer chiral peptide nucleic acid (PNA) sequences containing hydroxyl and imidazole groups were designed and synthesized by solid phase synthesis method after the classical PNA monomers were replaced by chiral PNA monomers containing serine or histidine residue. The structures of PNA analogues were confirmed by ESI-MS or MALDI-TOF-MS.

Key words: synthesis, hydroxyl group, imidazole, chiral peptide nucleic acid