Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (07): 975-978. Previous Articles     Next Articles

Reports

研磨法合成1,2,3,6-四氢嘧啶-2-酮衍生物

靳通收*,赵莹,刘利宾,李同双   

  1. (河北大学化学与环境科学学院 保定 071002)
  • 收稿日期:2005-06-14 修回日期:2006-01-18 发布日期:2006-07-01
  • 通讯作者: 靳通收

Synthesis of 1,2,3,6-Tetrahydropyrimidin-2-one Derivatives by Grinding Method

JIN Tong-Shou*,ZHAO Ying,LIU Li-Bin,LI Tong-Shuang   

  1. (College of Chemistry and Environmental Science, Hebei University, Baoding 071002)
  • Received:2005-06-14 Revised:2006-01-18 Published:2006-07-01
  • Contact: JIN Tong-Shou

NH2SO3H was used to efficiently perform one-pot, three-component, Biginelli condensation reactions of aldehydes, β-ketoesters and urea under solvent-free conditions at room temperature by grinding method. The method offered several advantages including mild reaction conditions, simple experimental procedure, environmental friendliness and excellent yield.

Key words: synthesis, grinding method, 1,2,3,6-tetrahydropyrimidin-2-one, aminosulfonic acid