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Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (9): 1313-1316. Previous Articles     Next Articles

Reports

含十五内酯环磺酰脲类化合物的合成

朱伟娟，梁晓梅，陈卫华，吴景平，王道全*   

  1. (中国农业大学应用化学系 北京 100094)
  • 收稿日期:2005-10-06 修回日期:2006-02-09 发布日期:2006-09-11
  • 通讯作者: 王道全

Synthesis of Sulfonylureas Containing 1,15-Pentadecanolide Ring

ZHU Wei-Juan,LIANG Xiao-Mei,CHEN Wei-Hua
WU Jing-Ping,WANG Dao-Quan*   

  1. (Department of Applied Chemistry, China Agricultural University, Beijing 100094)
  • Received:2005-10-06 Revised:2006-02-09 Published:2006-09-11
  • Contact: WANG Dao-Quan

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To simulate the structure of the natural products, five sulfonyl ureas containing pentadecanolide ring (4) were synthesized from 2-nitrocyclododecanone by the Michael addition with acrolein followed by ring enlargement and introduction of the sulfonylurea side chain. Their structures were confirmed by 1H NMR, IR spectra and elemental analysis. The preliminary bioassay showed that they have some herbicidal activity, among them 4c exhibits the highest activity, and the LC50 values against Digitaria Sanguinalis (L.) Scrop and Abutilon theophrastic Medic are 27.4 and 71.8 mg/L respectively.

Key words: macrolide, synthesis, herbicidal activity, sulfonylurea