O-Phospho-L-serine and its derivatives, having important pharmacology activity and bioactivity, were synthesized by the reaction of phosphorusoxychloride partially prehydrolyzed and L-serine. The crystal of O-phospho-L-serine was incubated and the crystal structure was determined by X-ray single crystal diffraction method. Furthermore, calcium salt, diisopropylamine salt and di(diisopropylamine) salt of O-phospho-L-serine were also synthesized. The structures of products were identified by NMR, IR and MS spectra.

Key words: O-phospho-L-serine, synthesis, derivative, L-serine