Synthesis and Herbicidal Activity of 3-(Un)substitutedBenzy-loxy-6-fluoropyridazines

Abstract

A series of novel 3-(un)substituted benzyloxy-6-fluoropyridazine derivatives were synthesized by reaction of different benzyl alcohols with 3,6-difluoropyridazine in CH₃CN catalyzed by NaOH. Their structures were identified by ¹H NMR, IR spectra and elemental analysis. Preliminary bioassay showed that all of them possessed some extent herbicidal activity against Brassica napus and Echinochloa crusgalli, and the structure-activity relationship was discussed.

Key words: synthesis, herbicidal activity, structure-acti- vity relationship, 3-(un)substituted benzyloxy-6-fluoropyridazine

Cite this article

ZHANG Min, HU Fang-Zhong, ZHU You-Quan
ZOU Xiao-Mao, LIU Bin YANG Hua-Zheng*. Synthesis and Herbicidal Activity of 3-(Un)substitutedBenzy-loxy-6-fluoropyridazines[J]. Chin. J. Org. Chem., 2007, 27(06): 749-752.

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3-(未)取代苄氧基-6-氟哒嗪的合成及其除草活性