Solvent-Free One-Pot Process for the Synthesis of Tetrahydro-benzo[b]-γ-pyran Derivatives under Grinding

Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (08): 1018-1021. Previous Articles Next Articles

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无溶剂研磨条件下四氢苯并吡喃衍生物的一锅法合成

张慧*，曹卫国，任仲皎

(上海大学化学系上海 200444)

收稿日期:2006-08-31 修回日期:1900-01-01 发布日期:2007-07-30
通讯作者: 张慧*

Solvent-Free One-Pot Process for the Synthesis of Tetrahydro-benzo[b]-γ-pyran Derivatives under Grinding

ZHANG Hui*, CAO Wei-Guo, REN Zhong-Jiao

(Department of Chemistry, Shanghai University, Shanghai 200444)

Received:2006-08-31 Revised:1900-01-01 Published:2007-07-30
Contact: ZHANG Hui*

Abstract

Tetrahydrobenzo[b]-γ-pyran derivatives are useful intermediates in organic synthesis and are found in a large number of biologically active compounds. K₂CO₃ as the base, aromatic aldehyde, malononitrile and 5,5-dimethyl-1,3-cyclohexanedione were condensed to form tetrahydrobenzo[b]-γ-pyran derivatives in a solvent-free one-pot process under grinding. The advantages of this process are high efficiency, easy work-up, mildness, high yield and environmental compatibility.

Key words: solvent-free, one-pot process, grinding, tetrahydrobenzo[b]-γ-pyran

Cite this article

ZHANG Hui*, CAO Wei-Guo, REN Zhong-Jiao. Solvent-Free One-Pot Process for the Synthesis of Tetrahydro-benzo[b]-γ-pyran Derivatives under Grinding[J]. Chin. J. Org. Chem., 2007, 27(08): 1018-1021.

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无溶剂研磨条件下四氢苯并吡喃衍生物的一锅法合成

Solvent-Free One-Pot Process for the Synthesis of Tetrahydro-benzo[b]-γ-pyran Derivatives under Grinding

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