Study on the Synthesis and Anticoccidial Activity of Ethyl 6-Aryloxy-4-hydroxy-3-quinolinecarboxylates

Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (08): 981-984. Previous Articles Next Articles

Original Articles

6-芳氧基-4-羟基-3-喹啉羧酸乙酯的合成及抗球虫活性的研究

邹燕^a，吴凯群^a，杨祖幸^a，王玉良*^,a，侯太平^b，陈淑华^a

(^a四川大学化学学院成都 610064)
(^b四川大学生命科学学院成都 610064)

收稿日期:2006-10-08 修回日期:1900-01-01 发布日期:2007-07-30
通讯作者: 王玉良*

Study on the Synthesis and Anticoccidial Activity of Ethyl 6-Aryloxy-4-hydroxy-3-quinolinecarboxylates

ZOU Yan^a, WU Kai-Qun^a, YANG Zu-Xing^a, WANG Yu-Liang*^,a
HOU Tai-Ping^b CHEN Shu-Hua^a

(^aCollege of Chemistry, Sichuan University, Chengdu 610064)
(^bCollege of Life Science, Sichuan University, Chengdu 610064)

Received:2006-10-08 Revised:1900-01-01 Published:2007-07-30
Contact: WANG Yu-Liang*

Abstract

Eight ethyl 6-aryloxy-4-hydroxy-3-quinolinecarboxylates have been designed and synthesized. The new process is characterized by short synthetic route, high yield and cheap raw materials, which is convenient for the commercial production. Structures of the new compounds have been confirmed by ¹H NMR, MS, IR spectra and elemental analysis. Three of the new compounds were chosen for the anticoccidial activity test and the result had shown that ethyl 4-hydroxy-6-(2-methoxyphenoxy)-3-quinolinecarboxylate (4f) has anticoccidial activity and can be used as an anticoccidial medicine.

Key words: synthesis, anticoccidial activity, ethyl 6-aryloxy-4-hydroxy-3-quinolinecarboxylate

Cite this article

ZOU Yan^a, WU Kai-Qun^a, YANG Zu-Xing^a, WANG Yu-Liang*^,a
HOU Tai-Ping^b CHEN Shu-Hua. Study on the Synthesis and Anticoccidial Activity of Ethyl 6-Aryloxy-4-hydroxy-3-quinolinecarboxylates[J]. Chin. J. Org. Chem., 2007, 27(08): 981-984.

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6-芳氧基-4-羟基-3-喹啉羧酸乙酯的合成及抗球虫活性的研究

Study on the Synthesis and Anticoccidial Activity of Ethyl 6-Aryloxy-4-hydroxy-3-quinolinecarboxylates

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