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Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (12): 1530-1536. Previous Articles     Next Articles

Original Articles

3-取代苄氧基-6-取代氨基哒嗪衍生物的合成及其除草活性

胡方中，张敏，朱有全，邹小毛，刘斌，杨华铮*   

  1. (南开大学元素有机化学研究所 元素有机化学国家重点实验室 天津 300071)
  • 收稿日期:2007-01-19 修回日期:2007-05-14 发布日期:2007-12-04
  • 通讯作者: 杨华铮

Synthesis and Herbicidal Activity of 3-(Substituted benzyloxy)- 6-(substituted amino)pyridazines

HU Fang-Zhong, ZHANG Min, ZHU You-Quan
ZOU Xiao-Mao, LIU Bin, YANG Hua-Zheng*   

  1. (State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University,
    Tianjin 300071)
  • Received:2007-01-19 Revised:2007-05-14 Published:2007-12-04
  • Contact: YANG Hua-Zheng

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A series of new 3-(substituted benzyloxy)-6-(substituted amino)pyridazines were synthesized through the reaction of 3-(substituted benzyloxy)-6-fluoropyridazines with the solution of dimethylamine in absolute ethanol in a sealed tube in 75～80 ℃ or with morpholine or piperidine under reflux, respectively. The title compounds were identified by IR, 1H NMR spectra and elemental analyses. Preliminary bioassay showed that some of them had certain extent herbicidal activities, and the structure-activity relationship was also discussed.

Key words: synthesis, herbicidal activity, structure- activity relationship, 3-(substituted benzyloxy)-6-(substituted amino)pyridazine