Synthesis of 5-Amino-1,3-dihydro-1,3-dioxo-isoindole-2-propanoic Acid Derivatives and Their Antiangiogenic Activities

Abstract

Based on the structure-activity relationships of RGD-containing peptides, a series of novel 5-amino-1,3-dihydro-1,3-dioxo-isoindole derivatives were designed and synthesized. The intermediates and target compounds were characterized by ¹H NMR, MS spectra and elemental analysis. Their ability to inhibit angiogenesis was evaluated in the chick embryo chorioallantoic membrane assay at 10^－5 mol/L. Some compounds displayed obviously antiangiogenic activity induced by basic fibroblast growth factor.

Key words: synthesis, antiangiogenic, 5-amino-1,3-dihydro-1,3-dioxo-isoindole derivative, RGD sequence peptide

Cite this article

WU Bei^a,YANG Da-Cheng^b,SHEN Yi^a,DENG Yong*^,a,ZHONG Yu-Guo^a. Synthesis of 5-Amino-1,3-dihydro-1,3-dioxo-isoindole-2-propanoic Acid Derivatives and Their Antiangiogenic Activities[J]. Chin. J. Org. Chem., 2007, 27(9): 1110-1115.

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