Three-Component One-Pot Synthesis of 1-Aryl-4-benzo[f]quinoline Derivatives in Aqueous Media

Abstract

A series of 1-aryl-1,2-dihydrobenzo[f]quinolin-3(4H)-one derivatives were synthesized by a three-component one-pot reaction of benzaldehyde, naphthalene-2-amine and meldrum’s acid at refluxing temperature catalyzed by triethylbenzylammonium chloride in water. This method has the advantages of milder reaction conditions, good yields (79%～87%) and environmental benignity. The structures of the products were characterized by melting points, IR, ¹H NMR spectra and elemental analysis.

Key words: water, triethylbenzylammonium chloride, synthesis, benzo[f]quinoline

Cite this article

ZHANG Mei-Mei^a,WANG Xiang-Shan*^,a,b,LI Qing^b
YAO Chang-Sheng^b,TU Shu-Jiang^b. Three-Component One-Pot Synthesis of 1-Aryl-4-benzo[f]quinoline Derivatives in Aqueous Media[J]. Chin. J. Org. Chem., 2008, 28(05): 881-884.

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水介质中三组分一锅合成1-芳基苯并[f]喹啉衍生物