Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (06): 937-945.     Next Articles

Review

立体选择性还原的硼试剂及其在手性药物合成中的应用

蔡正艳*,周伟澄   

  1. (上海医药工业研究院 创新药物与制药工艺国家重点实验室 上海 200437)
  • 收稿日期:2007-06-06 修回日期:2007-09-19 发布日期:2008-06-26
  • 通讯作者: 蔡正艳

Application of Some Boron Reagents to Stereoselective Reduction in Synthesis of Chiral Drugs

CAI Zheng-Yan*, ZHOU Wei-Cheng   

  1. (State Key Laboratory of New Drug & Pharmaceutical Process, Shanghai Institute of Pharmaceutical Indus-try,
    Shanghai 200437)
  • Received:2007-06-06 Revised:2007-09-19 Published:2008-06-26
  • Contact: CAI Zheng-Yan

Boron reagents have been applied widely to the synthesis of chiral drugs. This paper reviews the recent applications of chiral boron reagents, alkyl boranes and the derivatives of sodium borohydride to chiral drug synthesis via the stereoselective reduction of ketones to chiral alcohols. The potential of these boron reagents for industrialization is discussed.

Key words: stereoselectivity, chiral drug, boron reagent