1,3-Diphenylthiourea could be substituted by achiral or chiral amines. Using this method, a series of achiral and chiral thiourea derivatives have been synthesized in good to excellent yields. All the new compounds have been fully characterized by IR, 1H NMR, 13C NMR and HRMS spectra. The X-ray analysis of a single crystal of chiral thiourea 7d has shown that there are two kinds of molecules of different conformations in one crystal unit.

Key words: substitution, X-ray diffraction, chiral, thiourea