Using 6-chloropurine as a starting material, 6-fluoropurine derivatives were prepared through the reaction of halogen exchange. 6-Trifluoethoxylpurine derivatives were prepared through substitution by β,β,β-trifluoroethoxyl sodium, while 6-trifluomethylpurine derivatives were prepared by the trifluomethyl action with CF3COONa/CuI/DMF at 160 ℃. All of the products were characterized by 1H NMR, mass spectra and elemental analysis. Fungicidal activities of all compounds were tested, showing that compounds 2b and 4b have good activity to Bacillus subtillis, compounds 4a and 4b have good activity to Aspergillus niger, and compounds 3b and 4b have good activity to Cardida tropicals.

Key words: purine, trifluoroethoxyl, trifluoromethyl, preparation, fluorine