Synthesis and Anti-tumoractivities of Dibenzylbutylester Lignans and Their Analogues

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (12): 2107-2114. Previous Articles Next Articles

Original Articles

二苯丁脂类木脂素及衍生物的合成和抗肿瘤活性研究

夏亚穆^*,a ; 赫蕊^b; 丁一宁^a

(a青岛科技大学化工学院青岛 266042)
(b青岛科技大学数理学院青岛 266042)

收稿日期:2008-03-27 修回日期:2008-06-13 发布日期:2008-12-28
通讯作者: 夏亚穆

Synthesis and Anti-tumoractivities of Dibenzylbutylester Lignans and Their Analogues

XIA, Ya-Mu^*,a ; HE, Rui^b; DING, Yi-Ning^a

(a College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042)
(b College of Mathematics and Physics, Qingdao University of Science and Technology, Qingdao 266042)

Received:2008-03-27 Revised:2008-06-13 Published:2008-12-28
Contact: XIA, Ya-Mu

Abstract

A useful synthetic route to dibenzylbutylester lignans was described using piperonal and veratraldehyde as the starting materials. This method involves Stobbe condensation and alkylation reactions to give the skeleton of lignan, then fellowed by transformation of functional groups to get target compounds. By this route, ten dibenzylbutylester lignans were obtained, four of which were natural products. The products were tested against human tumors, and some compounds show better activity against breast cancer cells.

Key words: synthesis, dibenzylbutylester lignan, antitumor activity

Cite this article

XIA, Ya-Mu^*,a ; HE, Rui^b; DING, Yi-Ning^a. Synthesis and Anti-tumoractivities of Dibenzylbutylester Lignans and Their Analogues[J]. Chin. J. Org. Chem., 2008, 28(12): 2107-2114.

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二苯丁脂类木脂素及衍生物的合成和抗肿瘤活性研究

Synthesis and Anti-tumoractivities of Dibenzylbutylester Lignans and Their Analogues

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