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Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (12): 2166-2169. Previous Articles     Next Articles

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微波辐射下合成2-芳甲酰氨基-5-(2-三氟甲基苯并咪唑-1- 亚甲基)-1,3,4-噻二唑

张万权a ; 李燕萍a; 刘晨江*,a,b ; 王吉德a,b
   

  1. (a新疆大学化学化工学院 石油天然气精细化工教育部重点实验室 乌鲁木齐 830046)
    (b西安交通大学理学院 西安 710049)
  • 收稿日期:2007-12-21 修回日期:2008-04-29 发布日期:2008-12-28
  • 通讯作者: 李燕萍

Synthesis of 2-Aroylamino-5-(2-trifluoromethylbenzimidazol-1-ylmethyl)-1,3,4-thiadiazole under Microwave Irradiation

ZHANG, Wan-Quan a; LI, Yan-Pinga ; LIU, Chen-Jiang*,a,b; WANG, Ji-De a,b   


  1. (a Key Laboratory of Petroleum and Gas Fine Chemicals of Ministry of Education, College of Chemistry and
    Chemical Engineering, Xinjiang University, Urumqi 830046)
    (b School of Science, Xi’an Jiaotong University, Xi’an 710049)
  • Received:2007-12-21 Revised:2008-04-29 Published:2008-12-28
  • Contact: LIU, Chen-Jiang

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1-[(2-Trifluoromethylbenzimidazol-1-yl)acetyl]-4-aroylthiosemicarbazide derivatives 1a～1j were synthesized by the reaction of 1-hydrazinocarbonylmethyl-2-trifluoromethylbenzoimidazole with aroylisothiocyanate under microwave irradiation. Then compounds 1a～1j were cyclized in acetic acid to afford a series of novel 2-aroylamino-5-(2-trifluoromethylbenzimidazol-1-ylmethyl)-1,3,4-thiadiazole de-rivatives 2a～2j under microwave irradiation. In comparison, it was found that the process under microwave irradiation had many merits with short time, excellent yields and less secondary reactions. The structures of all the new compounds were confirmed by elemental analysis, IR and 1H NMR spectra.

Key words: 2-trifluoromethylbenzimidazole, synthes, aroylthiosemicarbazide, 1,3,4-thiadiazole, microwave irradiation