Synthesis and Antifungal Activity of Novel 1,5-Diphenyl- 1,4-pentadien-3-one Oxime Esters

Abstract

Fifteen 1,5-diphenyl-1,4-pentadien-3-one oxime esters were synthesized by the reaction of 1,5-diphenyl-1,4-pentadien-3-one oxmie with acyl chloride. Their structures were identified by elemental analysis, IR, ¹H NMR and ¹³C NMR spectra. The preliminary bioassay showed that compounds 3i and 3o had certain antifungal activities against Fusarium graminearum with rate of 51.1% and 53.45% at a concentration of 50 mg•L^－1 respectively, similarly to the control (hymexozole).

Key words: oxime ester, pentadienone, synthesis, antifungal activity

Cite this article

LI Shao-Bo,HU De-Yu,SONG Bao-An*,YANG Song,JIN Lin-Hong
XUE Wei,ZENG Song,WANG Jun,CHEN Zhuo, LU Ping
ZHOU Xia,FAN Ling-E. Synthesis and Antifungal Activity of Novel 1,5-Diphenyl- 1,4-pentadien-3-one Oxime Esters[J]. Chin. J. Org. Chem., 2008, 28(2): 311-316.

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新型1,5-二苯基-1,4-戊二烯-3-酮肟酯类化合物的合成及其抑菌活性研究