Synthesis of 2-[(Un)substituted phenyl]-5-(4-nitrobenzamido)- 1,3,4-thiadiazoles

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (01): 82-88. Previous Articles Next Articles

Original Articles

2-芳基-5-(4-硝基苯甲酰氨基)-1,3,4-噻二唑的合成

李英俊^*,a ; 丁万刚^a ; 靳焜^b ; 孙淑琴^a; 刘军^a ;
刘丽军^a ; 王金奎^a

(a辽宁师范大学化学化工学院大连 116029)
(b大连理工大学精细化工重点实验室大连 116012)

收稿日期:2008-03-17 修回日期:2008-06-03 发布日期:2009-01-20
通讯作者: 李英俊

Synthesis of 2-[(Un)substituted phenyl]-5-(4-nitrobenzamido)- 1,3,4-thiadiazoles

Li, Yingjun^*,a ; Ding, Wangang^a ; Jin, Kun^b ; Sun, Shuqin^a ; Liu, Jun^a;
Liu, Lijun^a; Wang, Jinkui^a

(a College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029)
(b State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012)

Received:2008-03-17 Revised:2008-06-03 Published:2009-01-20
Contact: Li, Yingjun

Abstract

Ten 1-(4-nitrobenzoyl)-4-[(un)substituted benzoyl]thiosemicarbazides 5a～5j were obtained by the reaction of (un)substituted-benzohydrazides with 4-nitrobenzoyl chloride under microwave irradiation and phase transfer catalysis. And then, nine 2-[(un)substituted phenyl]-5-(4-nitrobenzamido)-1,3,4-thiadia- zoles 6a～6i were synthesized by the compounds 5 under reflux in DMF. The compounds 5d, 5f～5j, 6b～6d and 6f～6i are new compounds. The two isomers of compounds 5 were demonstrated by IR and 1H NMR. The structures of the target compounds 6 were characterized by IR, 1H NMR spectra and elemental analysis.

Key words: synthesis, characterization, 1,3,4-thiadiazole

Cite this article

Li, Yingjun^*,a ; Ding, Wangang^a ; Jin, Kun^b ; Sun, Shuqin^a ; Liu, Jun^a;
Liu, Lijun^a; Wang, Jinkui^a
. Synthesis of 2-[(Un)substituted phenyl]-5-(4-nitrobenzamido)- 1,3,4-thiadiazoles[J]. Chin. J. Org. Chem., 2009, 29(01): 82-88.

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2-芳基-5-(4-硝基苯甲酰氨基)-1,3,4-噻二唑的合成

Synthesis of 2-[(Un)substituted phenyl]-5-(4-nitrobenzamido)- 1,3,4-thiadiazoles

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