Synthesis of 6-Amino-8-aryl-2-methyl-5,7,7(1H)-tricarbonitrile-2,3,8,8a- tetrahydroisoquinoline Derivatives under Solvent-Free Conditions Using a Ginding Method

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (06): 962-965. Previous Articles Next Articles

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无溶剂研磨合成6-氨基-8-芳基-2-甲基-5,7,7(1H)-三腈基-2,3,8,8a- 四氢异喹啉衍生物

荣良策^*,a,b ; 韩红霞^a ; 姜虹^b ; 庄启亚^a ; 王苏惠^a ; 屠树江^a,b

(a徐州师范大学化学化工学院徐州 221116)
(b江苏省药用植物生物技术重点实验室徐州 221116)

收稿日期:2008-05-13 修回日期:2008-12-28 发布日期:2009-06-20
通讯作者: 荣良策

Synthesis of 6-Amino-8-aryl-2-methyl-5,7,7(1H)-tricarbonitrile-2,3,8,8a- tetrahydroisoquinoline Derivatives under Solvent-Free Conditions Using a Ginding Method

Rong, Liangce^*,a,b ; Han, Hongxia^a; Jiang, Hong^b; Zhuang, Qiya ^a;
Wang, Suhui^a; Tu, Shujiang ^a,b

(a College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116)
(b Key Laboratory of Biotechnology for Medicinal Plant, Xuzhou 221116)

Received:2008-05-13 Revised:2008-12-28 Published:2009-06-20
Contact: Rong, Liangce

Abstract

A series of 6-amino-8-aryl-2-methyl-5,7,7(1H)-tricarbonitrile-2,3,8,8a-tetrahydroisoquinoline derivatives were synthesized from aromatic aldehydes, malononitrile and N-methylpiperidin-4-one in the presence of sodium hydroxide under a solvent-free condition. The advantages of this procedure were simple protocol and high yields. The structures of products were determined by IR, 1H NMR spectra, elemental analysis, and 4d was additionally confirmed by X-ray diffraction analysis .

Key words: malononitrile, grinding, N-methylpiperidin-4-one, solvent-free, aromatic aldehyde

Cite this article

Rong, Liangce^*,a,b ; Han, Hongxia^a; Jiang, Hong^b; Zhuang, Qiya ^a;
Wang, Suhui^a; Tu, Shujiang ^a,b
. Synthesis of 6-Amino-8-aryl-2-methyl-5,7,7(1H)-tricarbonitrile-2,3,8,8a- tetrahydroisoquinoline Derivatives under Solvent-Free Conditions Using a Ginding Method[J]. Chin. J. Org. Chem., 2009, 29(06): 962-965.

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无溶剂研磨合成6-氨基-8-芳基-2-甲基-5,7,7(1H)-三腈基-2,3,8,8a- 四氢异喹啉衍生物

Synthesis of 6-Amino-8-aryl-2-methyl-5,7,7(1H)-tricarbonitrile-2,3,8,8a- tetrahydroisoquinoline Derivatives under Solvent-Free Conditions Using a Ginding Method

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