Synthesis and Bioactivities of Hexahydropyridazine Derivatives

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (08): 1232-1235. Previous Articles Next Articles

Original Articles

六氢哒嗪衍生物的合成与生物活性研究

杜晓华^*,a ; 胡丽华^a; 孙祖光^a; 聂思桥^b ; 徐振元^a

(a浙江工业大学催化加氢研究中心杭州 310014)
(b湖南化工研究院长沙 410082)

收稿日期:2008-10-18 修回日期:2008-12-30 发布日期:2009-08-30
通讯作者: 杜晓华

Synthesis and Bioactivities of Hexahydropyridazine Derivatives

Du, Xiaohua^*,a; Hu, Lihua^a; Sun, Zuguang ^a;Nie, Siqiao ^b; Xu, Zhenyuan^a

(a Catalytic Hydrogenation Research Center, Zhejiang University of Technology, Hangzhou 310014)
(b Hunan Research Institute of Chemical Industry, Changsha 410082)

Received:2008-10-18 Revised:2008-12-30 Published:2009-08-30
Contact: Du, Xiaohua

Abstract

Thirteen novel hexahydropyridazine derivatives were synthesized based on hexahydropyridazine. And structurally confirmed by IR, 1H NMR and mass spectra. The crystal structures of 1a, 2a and 3a were determined by X-ray diffraction analysis. Preliminary bioassays show that some of the compounds have her-bicidal activities.

Key words: 1,2,4-triazolo[1,2-a]pyridazine, synthesis, hexahydropyridazine-1-carboxamide, herbicidal activi, hexahydropyridazine

Cite this article

Du, Xiaohua^*,a; Hu, Lihua^a; Sun, Zuguang ^a;Nie, Siqiao ^b; Xu, Zhenyuan^a. Synthesis and Bioactivities of Hexahydropyridazine Derivatives[J]. Chin. J. Org. Chem., 2009, 29(08): 1232-1235.

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六氢哒嗪衍生物的合成与生物活性研究

Synthesis and Bioactivities of Hexahydropyridazine Derivatives

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