A series of novel 1,3,4-oxadiazole title compounds were synthesized by the Huisgen reaction from 2-(4-(1H-tetrazol-5-yl)phenoxy)propanoate/acetate。The latter was obtained via 4-cyanophenol and ethyl 2-chloropropanoate (or methyl 2-chloroacetate) as starting materials。Structures of the title compounds were confirmed by 1H NMR，13C NMR，MS，IR techniques and elemental analysis or FT-MS，and the structure of 3q was determined by X-ray single crystal diffraction method。The preliminary bioassay indicates that compounds 3c and 3d with small volume substituents on the oxadiazole ring showed 94.5% and 83.1% inhibitory activities on rice KARI at a test concentration of 200 μg/mL，repectively。Compound 3p displayed 82.4% inhibition on rape root (Brassica campestris) at 100 μg/mL concentration in herbicidal tests.

Key words: oxadiazole, synthesis, crystal structure, biological activity