Six unreported (S)-(＋)-N-substituted pyrrolidinyl methanol deivatives 3a～3f were synthesized with L-α-proline as raw materials via esterification, N-alkylation and Grignard reaction. The structures of all newly synthesized compounds were elucidated and confirmed by elemental analysis, IR and ¹H NMR spectra. The crystal structure of (S)-(＋)-1-[N-(5-chloro-2-thiazolmethyl)pyrrolidin-2-yl]-1,1-diphenylmethanol (3e) was determined by X-ray diffraction analysis, which belongs to the monoclinic system, space group P2(1) with a＝0.8737(14) nm, b＝0.9098(14) nm, c＝1.2180(17) nm, α＝90.00°, β＝92.55(3)°, γ＝90.00°, V＝0.9671(3) nm³, Z＝2, D_c＝1.3217 g/cm³, F(000)＝404, R＝0.0584, and wR＝0.1335.

Key words: N-substituted pyrrolidinyl methanol, crystal structure, synthesis