Recent Advances in the Bio-catalytic Synthesis of α-Cyanohydrins

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (05): 662-674. Previous Articles Next Articles

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α-氰醇的生物催化合成新进展

陈沛然*，颜超，张怡

(东华大学化学化工与生物工程学院上海 201620)

收稿日期:2009-10-25 修回日期:2010-01-29 发布日期:2010-03-30
通讯作者: 陈沛然 E-mail:prchen@dhu.edu.cn
基金资助:
国家级.国家自然科学基金

Recent Advances in the Bio-catalytic Synthesis of α-Cyanohydrins

CHEN Pei-Ran, YAN Chao, ZHANG Yi

(College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620)

Received:2009-10-25 Revised:2010-01-29 Published:2010-03-30
Contact: Chen Pei-Ran E-mail:prchen@dhu.edu.cn

Abstract

Recent advances in the bio-catalytic synthesis of α-cyanohydrins are reviewed. New descriptions of HNL (hydroxynitrile lyase) catalytic mechanism, new investigation in the reaction system (including the modification of HNL, reaction media, and reactor), as well as the hydrocyanation of a series of aldehydes and ketones, which has not been reported in the prevenient reviews, are summarized.

Key words: α-cyanohydrins, bio-catalysis, hydroxynitrile lyase, asymmetric hydrocyanation, reaction mechanism

Cite this article

CHEN Pei-Ran, YAN Chao, ZHANG Yi. Recent Advances in the Bio-catalytic Synthesis of α-Cyanohydrins[J]. Chin. J. Org. Chem., 2010, 30(05): 662-674.

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α-氰醇的生物催化合成新进展

Recent Advances in the Bio-catalytic Synthesis of α-Cyanohydrins

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