Acetonylacetone was treated with amine (aminothiourea, thiourea, aniline, amino acid) to give six 2,5-dimethyl-N-substitute derivatives by Paal-Knorr reaction. Using the new N-pyrrole glycin and N-phenyl pyrrole compounds as materials, three N-(2,5-dimethyl pyrrole) glycin esters and two N-phenyl-2,5-dimethyl pyrrole derivatives were obtained via esterification reaction and Mannich, Friedel-Craft reactions, respectively. The structures of all the compounds were confirmed by IR, H NMR, C NMR and HRMS spectra.

Key words: acetonylacetone, Paal-Knorr reaction, pyrrole, synthesis