Sixteen new dihydropyridine calcium antagonists  and  were designed and synthesized based on 5-(methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid ()or diketene. The structures of the target compounds were confirmed byIR,H NMR, ESI-MS techniques and elemental analysis. The results of preliminary pharmacological test showed that compounds , ,, and had obvious relaxation effect on the contraction of vascular ring of aorta induced by KCl, which were better than positive control (levoamlodipine besylate).

Key words: dihydropyridine calcium antagonist, synthesis, biological activity