Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (11): 1764-1767. Previous Articles     Next Articles

Notes

氯化硅胶催化下无溶剂合成香豆素类化合物

武利强*,闫福林,杨春广,杨利敏   

  1. (新乡医学院药学院 新乡 453003)
  • 收稿日期:2009-11-15 修回日期:2010-03-24 发布日期:2010-06-24
  • 通讯作者: 武利强 E-mail:wliq1974@sohu.com

Silica Chloride Catalyzed Solvent-Free Synthesis of Coumarins

WU Li-Qiang, YAN Fu-Lin, YANG Chun-Guang, YANG Li-Min   

  1. (School of Pharmacy, Xinxiang Medical University, Xinxiang 453003)
  • Received:2009-11-15 Revised:2010-03-24 Published:2010-06-24

Using silica chloride as a catalyst, a series of coumarins were synthesized by Pechmann reaction of β-keto esters with phenols at 80 ℃ and solvent-free conditions. This method has the advantages of mild reaction conditions, high yields (67%~96%) and easy operation. All products were characterized by IR, 1H NMR spectra and elemental analysis.

Key words: silica chloride, coumarins, Pechmann reation, synthesis