Microwave-Assisted Synthesis of Oxadiazoline Derivatives Contain-ing Indole Structure and Their Antibacterial Activities

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (12): 1949-1954. Previous Articles Next Articles

Notes

微波辐射下吲哚连噁二唑啉衍生物的合成和抗菌活性测定

赵志刚*，刘兴利，陈宇，李辉，石治川

(西南民族大学化学与环境保护工程学院成都 610041)

收稿日期:2010-05-07 修回日期:2010-06-30 发布日期:2010-07-23
通讯作者: 赵志刚 E-mail:zzg63129@yahoo.com.cn
基金资助:
国家民委自然科学基金

Microwave-Assisted Synthesis of Oxadiazoline Derivatives Contain-ing Indole Structure and Their Antibacterial Activities

ZHAO Zhi-Gang, LIU Xing-Li, CHEN Yu, LI Hui, SHI Zhi-Chuan

(College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041)

Received:2010-05-07 Revised:2010-06-30 Published:2010-07-23
Contact: Zhi-Gang ZHAO E-mail:zzg63129@yahoo.com.cn

Abstract

A novel type of 6-substituted indole compounds has been designed and synthesized by connecting the structure of oxdiazoline to indole ring, with a view of providing lead compounds for the screening of new drugs. Under the condition of microwave irradiation, nine new compounds have been obtained with high yields, and the structures of all new compounds were characterized by IR, ¹H NMR, MS techniques and elemental analysis. The antibacterial activities of compounds have been tested against two kinds of bacteria. The preliminary results showed that the compounds possess different inhibitive effects.

Key words: indole, oxdiazoline, microwave irradiation, antibacterial activity

Cite this article

ZHAO Zhi-Gang, LIU Xing-Li, CHEN Yu, LI Hui, SHI Zhi-Chuan. Microwave-Assisted Synthesis of Oxadiazoline Derivatives Contain-ing Indole Structure and Their Antibacterial Activities[J]. Chin. J. Org. Chem., 2010, 30(12): 1949-1954.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

[1]	Qinggang Mei, Qinghan Li. Recent Progress of Visible Light-Induced the Synthesis of C(3) (Hetero)arylthio Indole Compounds [J]. Chinese Journal of Organic Chemistry, 2024, 44(2): 398-408.
[2]	Haibo Huo, Guixia Li, Shijun Wang, Chun Han, Baojun Shi, Jian Li. Novel γ-Carboline Derivatives as Antibacterial Agents: Synthesis and Antibacterial Evaluation [J]. Chinese Journal of Organic Chemistry, 2024, 44(1): 204-215.
[3]	Wenfeng Bei, Jian Pan, Dongmei Ran, Yilin Liu, Zhen Yang, Ruokun Feng. Cobalt-Catalyzed [4+2] Annulation of Indole Carboxamide with Diynes and Monoacetylene: Direct Access to γ-Carbolinones [J]. Chinese Journal of Organic Chemistry, 2023, 43(9): 3226-3238.
[4]	Weizhong Ding, Bingwen Zhang, Yanqing Xue, Yuqi Lin, Zhijun Tang, Jing Wang, Wenchao Yang, Xiaofeng Wang, Wen Liu. A New Polyketide from Fusarium graminearum [J]. Chinese Journal of Organic Chemistry, 2023, 43(9): 3319-3322.
[5]	Dandan Sui, Nannan Cen, Ruoqu Gong, Yang Chen, Wenbo Chen. Supporting-Electrolyte-Free Electrochemical Synthesis of Trifluoromethylated Oxindoles in Continuous Flow [J]. Chinese Journal of Organic Chemistry, 2023, 43(9): 3239-3245.
[6]	Yi Wang, Jian Zhang, Yangzi Liu, Xiaoyan Luo, Weiping Deng. Palladium-Catalyzed Asymmetric [3＋4] Cycloadditions for the Construction of Cyclohepta[b]indoles [J]. Chinese Journal of Organic Chemistry, 2023, 43(8): 2864-2877.
[7]	Yingke Feng, He Wang, Mengxing Cui, Ran Sun, Xin Wang, Yang Chen, Lei Li. Visible-Light-Induced Difluoroalkylated Cyclization of Novel Functionalized Aromatic Isocyanides [J]. Chinese Journal of Organic Chemistry, 2023, 43(8): 2913-2925.
[8]	Lixing Sun, Tingting Sun, Haiqing Wang, Shufang Wu, Xiaoye Wang, Tianya Liu, Yuchen Zhang. Lewis Acid-Catalyzed [2+4] Cyclization of 3-Alkyl-2-vinylindoles with α,β-Unsaturated N-Sulfonyl Ketimines [J]. Chinese Journal of Organic Chemistry, 2023, 43(6): 2178-2188.
[9]	Zeren Sun, Bingxin Zhai, Guangchao He, Hui Shen, Linya Chen, Shan Zhang, Yi Zou, Qihua Zhu, Yungen Xu. Synthesis and Anti-inflammatory Evaluation of Novel 1,2,3-Triazole Derivatives [J]. Chinese Journal of Organic Chemistry, 2023, 43(6): 2143-2155.
[10]	Mingyang Pang, Honghong Chang, Zhang Feng, Juan Zhang. Recent Advances in Transition-Metal-Catalyzed Tandem Dearomatization of Indoles [J]. Chinese Journal of Organic Chemistry, 2023, 43(4): 1271-1291.
[11]	Hua Huang, Xin Li, Jianke Su, Qiuling Song. Difluorocarbene-Enabled Synthesis of 3-Substituted-2-oxoindoles from o-Vinylanilines [J]. Chinese Journal of Organic Chemistry, 2023, 43(3): 1146-1156.
[12]	Jinxiao Zhao, Tonghui Wei, Sen Ke, Yi Li. Visible Light-Catalyzed Synthesis of Difluoroalkylated Polycyclic Indoles [J]. Chinese Journal of Organic Chemistry, 2023, 43(3): 1102-1114.
[13]	Changyuan Du, Yucai Tang, Jinglin Duan, Biyu Yang, Yupeng He, Qian Zhou, Xuewen Liu. Organic-Dye-Catalyzed Visible-Light-Mediated Alkoxycarbon-ylation of 2-Aryl-N-acryloyl Indoles with Carbazates [J]. Chinese Journal of Organic Chemistry, 2023, 43(12): 4268-4276.
[14]	Tiantian Liu, Xinhong Duan. Recent Progress in the Construction of Chiral 3-Substituted Indoles by Asymmetric Friedel-Crafts Reactions [J]. Chinese Journal of Organic Chemistry, 2023, 43(11): 3695-3712.
[15]	Xuechun Zhao, Hui Fan, Yao Xu, Xiaoming Liao, Xiaoxiang Zhang. PPh₃-Mediated Synthesis of 3-Hydroxy-2-oxindoles from o-Alkynylnitrobenzenes [J]. Chinese Journal of Organic Chemistry, 2023, 43(11): 3997-4002.

微波辐射下吲哚连噁二唑啉衍生物的合成和抗菌活性测定

Microwave-Assisted Synthesis of Oxadiazoline Derivatives Contain-ing Indole Structure and Their Antibacterial Activities

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments