Advances of Enantioselective Addition of Terminal Alkynes to Imines and Their Derivatives

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (9): 1261-1269. Next Articles

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末端炔与亚胺及衍生物的不对称加成反应研究进展

边庆花，钟江春，侯士聪*，王敏

(中国农业大学理学院北京 100193)

收稿日期:2009-07-18 修回日期:2009-12-10 发布日期:2010-02-23
通讯作者: 侯士聪 E-mail:houshc@cau.edu.cn
基金资助:
国家级.国家自然科学基金

Advances of Enantioselective Addition of Terminal Alkynes to Imines and Their Derivatives

BIAN Qing-Hua, ZHONG Jiang-Chun, HOU Shi-Cong, WANG Min

(College of Sciences, China Agricultural University, Beijing 100193)

Received:2009-07-18 Revised:2009-12-10 Published:2010-02-23
Contact: Hou Shi-Cong Hou E-mail:houshc@cau.edu.cn

Abstract

Recent advances of enantioselective additions of terminal alkynes to imines are reviewed in this paper. The asymmetric catalysts involve the homogeneous and immobilized ones. The homogeneous ones comprise copper complexes of Pybox, bisamines, Quinap, Pinap and tosylated aminoimine, zirconium com-plexes of peptidic chiral ligands, zinc complexes of aminoalcohols and Binols etc. The three-component addition reactions of terminal alkynes, aldehydes and amines are also discussed.

Key words: alkynylation, imine, asymmetric, three-component reaction, progress

Cite this article

BIAN Qing-Hua, ZHONG Jiang-Chun, HOU Shi-Cong, WANG Min. Advances of Enantioselective Addition of Terminal Alkynes to Imines and Their Derivatives[J]. Chin. J. Org. Chem., 2010, 30(9): 1261-1269.

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末端炔与亚胺及衍生物的不对称加成反应研究进展

Advances of Enantioselective Addition of Terminal Alkynes to Imines and Their Derivatives

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