Four novel estrogen derivatives were synthesized by a one-step reaction with 17α-ethynylestradiol and 17β-estradiol as the initial materials, reacted with allyl bromide and isopentenyl bromide, respec-tively, obtained 17α-ethynylestradiol-3-allyl ether (ES-1), 17β-estradiol-3-allyl ether (ES-2), 17α-ethyny- lestradiol-3-isopentenyl ether (ES-3) and 17β-estradiol-3-isopentenyl ether (ES-4), in yields of 92.2%, 73.7%, 65.9% and 67.6%. And the structures of products were conformed by ¹H NMR, ¹³C NMR, MS, IR techniques and elemental analysis. The four compounds are novel estrogens without paper reported. The initial research of biological activities on anti-radiation promotion white blood cells (WBC) were carried out, and the results suggested that the four compounds possess certain protective effects to 6.5Gy ¹³⁷Cs γ-rays damages on lowered WBC and haematogenesis system function, promotion WBC effect of ES-3 with obvious preponderance was best in the four products. The effect of promotion WBC for three dosages of ES-3 administered mice, treated by statistics with very obvious difference (P＜0.001) vs. control mice.

Key words: estrogen, derivative, synthesis, anti-irradiation, promotion white blood cell (WBC)