Synthetic Methods and Biological Activities of Clitocine and Its Ana-logues

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (02): 176-186. Previous Articles Next Articles

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克力托辛(Clitocine)及其类似物的合成与生物活性

郭翔海*^{,1，康宏²，郑岚曦²，姜申德*^,2}

(¹天津大学化工学院系统生物工程教育部重点实验室天津 300072)
(²天津大学药物科学与技术学院天津 300072)

收稿日期:2010-05-13 修回日期:2010-06-22 发布日期:2010-07-08
通讯作者: 郭翔海 E-mail:guoxh@tju.edu.cn

Synthetic Methods and Biological Activities of Clitocine and Its Ana-logues

Guo Xianghai*^{,1 Kang Hong² Zheng Lanxi² Jiang Shende*^,2}

(¹ Key Laboratory of Systems Bioengineering, Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072)
(² School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072)

Received:2010-05-13 Revised:2010-06-22 Published:2010-07-08

Abstract

Clitocine is a naturally occurring amino exocyclic nucleoside isolated from the mushroom Clitocybe inversa. It and its analogues have high bioactivities. In this review, the synthetic methods of clitocine, 2 -deoxy clitocine, aglycone-modified clitocine, 5 -deoxy clitocine, carbosugar clitocine and acyclic clitocine analogues are summarized. The application of clitocine and its analogues to study on insecticidal agent, adenosine kinase (AKase) inhibitor, antiviral and antitumor drugs is presented as well.

Key words: clitocine, synthesis, nucleoside analogue, antiviral, antitumor

Cite this article

GUO Xiang-Hai, KANG Hong, ZHENG Lan-Xi, JIANG Shen-De. Synthetic Methods and Biological Activities of Clitocine and Its Ana-logues[J]. Chin. J. Org. Chem., 2011, 31(02): 176-186.

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克力托辛(Clitocine)及其类似物的合成与生物活性

Synthetic Methods and Biological Activities of Clitocine and Its Ana-logues

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