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Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (05): 684-689. Previous Articles     Next Articles

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黄酮-6-羧酸类化合物的合成、表征和抑菌活性

温辉梁*,1，赖博文2，刘崇波3，龚云南3，陈云华2   

  1. (1南昌大学食品科学与技术国家重点实验室 南昌 330047)
    (2南昌大学理学院化学系 南昌 330031)
    (3南昌航空大学环境与化学工程学院 南昌 330063)
  • 收稿日期:2010-09-03 修回日期:2010-12-04 发布日期:2010-12-23
  • 通讯作者: 温辉梁 E-mail:hlwen70@163.com

Synthesis, Characterization and Antibacterial Activity of Six Fla-vone-6-carboxylic Acids

Wen Huiliang*,1 Lai Bowen2 Liu Chongbo3 Gong Yunnan3 Chen Yunhua2   

  1. (1 Key Laboratory of Food Science of Ministry of Education, Nanchang University, Nanchang 330047)
    (2 Department of Chemistry, Nanchang University, Nanchang 330031)
    (3 School of Environment and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063)
  • Received:2010-09-03 Revised:2010-12-04 Published:2010-12-23

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Six flavone-6-carboxylic acid compounds were synthesized via the chalcone route, and three of them were obtained in conditions of microwave radiation using I2/DMSO as the oxidant. Their structures were characterized by NMR, IR spectra and elemental analysis, and the crystal structure of flavone-6,4-dicarboxylic acid was further determined by X-ray single crystal diffraction technique. The pre-liminary biological activity tests show that the six compounds have antibacterial activity against Echerichia coli, Staphylococcus aureus and Bacillus subtilis.

Key words: flavone-6-carboxylic acid, synthesis, characterization, crystal structure, antibacterial activity