Twelve new compounds, 4-phenylamino quinazoline compounds 8a～8l, were synthesized from vanillin by the seven steps reaction. Their structures were characterized by ¹H NMR, ¹³C NMR, IR, MS techniques and elemental analysis. Compound 8b was investigated with X-ray crystallography. The crystal of 8b belongs to Triclinic, space group P-1 with cell parameters a＝0.8868(5) nm, b＝1.0239(6) nm, c＝1.4515(9) nm, α＝71.02(2)°, β＝82.42(2)°, γ＝71.78(2)°, V＝1.1831 nm³, Z＝2, D_c＝1.430 Mg/m³, μ(Mo Kα)＝1.773 mm^－1, λ＝0.071073 nm, F(000)＝522.

Key words: vanillin, quinazoline, synthesis, crystal structure