Synthesis and Characterization of New α-Aminophosphonates Containing 1H-Indazole Moiety

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (07): 1011-1019. Previous Articles Next Articles

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新型含1H-吲唑环的α-氨基膦酸酯的合成及表征

武现丽，魏成事，朱春风，吕志丹，廖新成*

(郑州大学化学系郑州 450052)

收稿日期:2010-10-19 修回日期:2011-01-20 发布日期:2011-02-17
通讯作者: 廖新成 E-mail:lucywu_005@163.com

Synthesis and Characterization of New α-Aminophosphonates Containing 1H-Indazole Moiety

WU Xian-Li, WEI Cheng-Shi, ZHU Chun-Feng, LV Zhi-Dan, LIAO Xin-Cheng

(Department of Chemistry, Zhengzhou University, Zhengzhou 450052)

Received:2010-10-19 Revised:2011-01-20 Published:2011-02-17
Contact: LIAO Xin-Cheng E-mail:lucywu_005@163.com

A series of novel 1H-indazole derivatives 6ma～6mk and 6na～6nk were synthesized via the nucleophilic addition reaction of phosphate esters 5m or 5n with Schiff bases 4a～4k, which were synthesized from nitration, reduction and condensation of aromatic aldehyde by using the 3-ethyl-1H-indazole (1) as starting material. The structures of new compounds were characterized by ¹H NMR, ¹³C NMR, ³¹P NMR, IR, MS and HRMS spectra.

Key words: α-aminophosphonate, 1H-indazole, synthesis

Cite this article

WU Xian-Li, WEI Cheng-Shi, ZHU Chun-Feng, LV Zhi-Dan, LIAO Xin-Cheng. Synthesis and Characterization of New α-Aminophosphonates Containing 1H-Indazole Moiety[J]. Chin. J. Org. Chem., 2011, 31(07): 1011-1019.

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新型含1H-吲唑环的α-氨基膦酸酯的合成及表征

Synthesis and Characterization of New α-Aminophosphonates Containing 1H-Indazole Moiety

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