Green Synthesis of 2-Arylquinazolin-4(1H)-one Derivatives Catalyzed by Yb(OTf)3 in Ionic Liquids

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (08): 1235-1239. Previous Articles Next Articles

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离子液体中Yb(OTf)₃催化下喹唑啉酮衍生物的绿色合成

王树良，杨科，王香善*

(徐州师范大学化学化工学院江苏省药用植物生物技术重点实验室徐州 221116)

收稿日期:2010-11-09 修回日期:2011-02-20 发布日期:2011-03-29
通讯作者: 王香善 E-mail:xswang1974@yahoo.com;xswang@xznu.edu.cn

Green Synthesis of 2-Arylquinazolin-4(1H)-one Derivatives Catalyzed by Yb(OTf)₃ in Ionic Liquids

WANG Shu-Liang, YANG Ke, WANG Xiang-Shan

(Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, School of Chemistry and Chemical En-gineering, Xuzhou Normal University, Xuzhou 221116)

Received:2010-11-09 Revised:2011-02-20 Published:2011-03-29
Contact: Wang Xiang-Shan E-mail:xswang1974@yahoo.com;xswang@xznu.edu.cn

A series of 2,3-dihydro-2-arylquinazolin-4(1H)-one derivatives were synthesized by the reaction of 2-aminobenzamide with aromatic aldehyde at room temperature catalyzed by Yb(OTf)₃ in ionic liquid of [BMIm]Br. Compared to the other methods, this method has the advantages of milder reaction conditions, higher yields (85%～96%) and environmental benignity. The structures of the products were characterized by melting points, IR, ¹H NMR and HRMS techniques.

Key words: quinazolin-4(1H)-one, ionic liquid, Yb(OTf)₃, synthesis

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WANG Shu-Liang, YANG Ke, WANG Xiang-Shan. Green Synthesis of 2-Arylquinazolin-4(1H)-one Derivatives Catalyzed by Yb(OTf)₃ in Ionic Liquids[J]. Chin. J. Org. Chem., 2011, 31(08): 1235-1239.

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离子液体中Yb(OTf)₃催化下喹唑啉酮衍生物的绿色合成

Green Synthesis of 2-Arylquinazolin-4(1H)-one Derivatives Catalyzed by Yb(OTf)₃ in Ionic Liquids

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离子液体中Yb(OTf)3催化下喹唑啉酮衍生物的绿色合成