Synthesis and Biological Activities of E-β-Farnesene Analogues Containing Substituent Nitroguanidine

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (12): 2061-2066. Previous Articles Next Articles

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含硝基胍E-β-法尼烯类似物的合成及生物活性研究

孙亮¹，凌云¹，王灿¹，孙玉凤¹，芮昌辉²，杨新玲*^,1

(¹中国农业大学理学院应用化学系北京 100193)
(²中国农业科学院植物保护研究所北京 100193)

收稿日期:2011-04-14 修回日期:2011-07-05 发布日期:2011-07-20
通讯作者: 杨新玲 E-mail:yangxl@cau.edu.cn

Synthesis and Biological Activities of E-β-Farnesene Analogues Containing Substituent Nitroguanidine

Sun Liang¹ Ling Yun¹ Wang Can¹ Sun Yufeng¹ Rui Changhui² Yang Xinling*^,1

(¹Department of Applied Chemistry, College of Science, China Agricultural Uni-versity, Beijing 100193)
(²Institute of Plant Protection, Chinese Academy of Agri-cultural Sciences, Beijing 100193)

Received:2011-04-14 Revised:2011-07-05 Published:2011-07-20

Chosing the E-β-farnesene (the main component of aphid alarm pheromones) as the lead compound, ten new compounds were designed and synthesized in which the conjugate double bond was replaced by different substituent nitroguanidine. Their structures were confirmed by ¹H NMR, IR spectra and HRMS analysis. The results of biological tests indicated that compounds showed insecticidal activity against Myzus persicae, especially the compounds 9a～9e showed higher insecticidal activity than that of E-β-farnesene.

Key words: nitroguanidine, E-β-farnesene, analogues, synthesis, aphicidal activity

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SUN Liang, LING Yun, WANG Can, SUN Yu-Feng, RUI Chang-Hui, YANG Xin-Ling. Synthesis and Biological Activities of E-β-Farnesene Analogues Containing Substituent Nitroguanidine[J]. Chin. J. Org. Chem., 2011, 31(12): 2061-2066.

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含硝基胍E-β-法尼烯类似物的合成及生物活性研究

Synthesis and Biological Activities of E-β-Farnesene Analogues Containing Substituent Nitroguanidine

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