Design and Synthesis of Novel Chiral Lithocholic Acid-Based Mole-cular Clefts Containing Unsymmetrically Disubstituted Urea Unit

Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (04): 513-518. Previous Articles Next Articles

Original Articles

新型手性不对称脲石胆酸分子裂缝的设计合成

周彩娥，赵志刚*，唐晓丽

(西南民族大学化学与环境保护工程学院成都 610041)

收稿日期:2006-09-11 修回日期:1900-01-01 发布日期:2007-03-29
通讯作者: 赵志刚

Design and Synthesis of Novel Chiral Lithocholic Acid-Based Mole-cular Clefts Containing Unsymmetrically Disubstituted Urea Unit

ZHOU Cai-E, ZHAO Zhi-Gang*, TANG Xiao-Li

(College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041)

Received:2006-09-11 Revised:1900-01-01 Published:2007-03-29
Contact: ZHAO Zhi-Gang

Abstract

A novel type of chiral molecular clefts has been designed and synthesized by linking a chiral unsymmetrically disubstituted urea to rigid methyl lithocholate via triphosgene. Seven molecular clefts are new compounds. Their structures were confirmed by ¹H NMR, IR, MS spectra and elemental analyses. The recognition properties of these molecular clefts for halogen anions have been investigated by UV-visible spectral titration. The preliminary results indicated that these molecular clefts not only possessed the ability to form 1∶1 complex with anions examined, but also showed good selectivity for halogen anions.

Key words: molecular cleft, synthesis, chiral unsymmetrical urea, lithocholic acid

Cite this article

ZHOU Cai-E, ZHAO Zhi-Gang*, TANG Xiao-Li. Design and Synthesis of Novel Chiral Lithocholic Acid-Based Mole-cular Clefts Containing Unsymmetrically Disubstituted Urea Unit[J]. Chin. J. Org. Chem., 2007, 27(04): 513-518.

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新型手性不对称脲石胆酸分子裂缝的设计合成

Design and Synthesis of Novel Chiral Lithocholic Acid-Based Mole-cular Clefts Containing Unsymmetrically Disubstituted Urea Unit

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