Studies of asymmetric cross-coupling reaction catalyzed  by chiral phosphine-transition metal complexes

Chin. J. Org. Chem. ›› 1993, Vol. 13 ›› Issue (5): 496-500. Previous Articles Next Articles

Original Articles

手性膦过渡金属配合物催化不对称交叉偶联反应的研究

王智贤;陈钟瑛

华东化工学院化学制药研究室

发布日期:1993-10-25

Studies of asymmetric cross-coupling reaction catalyzed by chiral phosphine-transition metal complexes

Wang Zhixian;Chen Zhongying

Published:1993-10-25

Abstract

Ferrocenylphosphine-PdCl~2 and 1, 2-bis(diphenylphosphine)-ethane- NiCl~2 complexes catalyzed Grignard cross-coupling of aryl bromide (1a- c) and sec-butylmagnesium bromide (2) with high yield and low to medium optical yield. The influences of reaction temperature and different pare-substituents on aryl bromide (1a-c) were studied, the structure of isomers was established by GC-MS analysis.

Key words: ASYMMETRY, LIGANDS, STEREOSELECTIVITY, TRANSITION METAL COMPLEX

CLC Number:

O627

Cite this article

Wang Zhixian;Chen Zhongying. Studies of asymmetric cross-coupling reaction catalyzed by chiral phosphine-transition metal complexes[J]. Chin. J. Org. Chem., 1993, 13(5): 496-500.

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手性膦过渡金属配合物催化不对称交叉偶联反应的研究

Studies of asymmetric cross-coupling reaction catalyzed by chiral phosphine-transition metal complexes

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